ឪសថ Aspirin

ACETYLSALICYLIN ACIDE = ASPIRIN

Therapeutic action 

– Analgesic, antipyretic, non steroidal anti-inflammatory (NSAID) 

– Platelet antiaggregant (at low dose) Indications

 – Mild pain, fever 

– Secondary prevention of severe pre-eclampsia

Presentation 

– 300 mg and 500 mg tablets 

– 75 mg enteric coated tablet 

Dosage and duration 

– Pain and fever

Adolescent over 16 years and adult: 300 mg to 1 g every 4 to 6 hours, without exceeding 4 g/day, for 1 to 3 days 

– Prevention of pre-eclampsia 75 mg once daily from the 12th to the 32nd week of gestation 

Contra-indications, adverse effects, precautions 

– Do not administer to patients with allergy to aspirin and NSAID, peptic ulcer, coagulation disorders,

hemorrhage, severe renal, hepatic or cardiac impairment. 

– Do not administer to children for pain or fever (use paracetamol). 

– Administer with caution to elderly patients or patients with asthma. 

– Do not exceed indicated doses, particularly in elderly patients. Intoxications are severe, possibly fatal. 

– May cause:

• allergic reactions, epigastric pain, peptic ulcer, haemorrhage;

• dizziness, tinnitus (early signs of overdose);

• Reye’s syndrome in children (encephalopathy and severe hepatic disorders). 

For all cases above, stop aspirin. 

– Do not combine with methotrexate, anticoagulants and NSAID. 

– Monitor combination with insulin (increased hypoglycaemia) and corticosteroids. 

– Pregnancy:

• pain and fever: avoid. 

Contra-indiCated from the beginning of the 6th month. Use paracetamol.

• prevention of pre-eclampsia: do not exceed 75 mg/day. 

– Breast-feeding: avoid. Use paracetamol. Remarks 

– Take during meals, preferably with a lot of water. 

– Do not crush enteric coated tablets. 

– Aspirin may be administered in secondary prevention of atherosclerosis, at a dose of 75 to 300 mg

Prescription under medical supervision