Wednesday, November 29, 2017

ឪសថ Azithromycin

Therapeutic action
 – Macrolide antibacterial Indications 
– Trachoma, conjunctivitis due to Chlamydia trachomatis 
– Cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea),donovanosis, chancroid, early syphilis 
– Cholera (if the strain is susceptible), yaws 
– Pertussis, pneumonia due to Mycoplasma pneumoniae and Chlamydophila pneumoniae 
– Streptococcal tonsillitis, acute otitis media, in penicillin-allergic patients only
Presentation 
– 250 mg and 500 mg capsules or tablets 
– 200 mg/5 ml powder for oral suspension, to be reconstituted with filtered water 
Dosage and duration 
Trachoma, cholera, cervicitis and urethritis due to C. trachomatis, chancroid, early syphilis
Child: 20 mg/kg as a single dose (max. 1 g) 
Adult: 1 g as a single dose (2 g as a single dose in early syphilis) 
Yaws 
Child and adult: 30 mg/kg as a single dose (max. 2 g) 
Conjunctivitis due to C. trachomatis
Child: 20 mg/kg once daily for 3 days (max. 1 g/day) 
Adult: 1 g once daily for 3 days 
Donovanosis (granuloma inguinale)
Adult: 1 g on D1 then 500 mg/day until healing of lesions 
Pertussis, pneumonia due to M. pneumoniae and C. pneumoniae
Child: 10 mg/kg once daily for 5 days (max. 500 mg/day) 
Adult: 500 mg on D1 then 250 mg from D2 to D5 
Streptococcal tonsillitis, only in penicillin-allergic patients
Child: 20 mg/kg once daily for 3 days (max. 500 mg/day) 
Adult: 500 mg once daily for 3 days 
Acute otitis media, only in penicillin-allergic patients
Child: 10 mg/kg once daily for 3 days (max. 500 mg/day) 
Contra-indications, adverse effects, precautions 
– Do not administer to patients with allergy to azithromycin or another macrolide, and to patients with severe hepatic impairment. 
– May cause: gastrointestinal disturbances, heart rhythm disorders (QT prolongation), allergic reactions sometimes severe. In the event of allergic reaction, stop treatment immediately. 
– Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.). Administer 2 hours apart. 
– Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, co artemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine, quinine, etc.). 
– Administer with caution and monitor use in patients taking digoxin (increased digoxin plasma levels).
 – Pregnancy and breast-feeding: no contra-indication 

2 មតិយោបល:

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